Neuroimaging of the Philadelphia Neurodevelopmental Cohort

Overview

Journal Neuroimage

Specialty Radiology

Date 2013 Aug 8

PMID 23921101

Citations 308

Authors

Theodore D Satterthwaite

Mark A Elliott

Kosha Ruparel

James Loughead

Karthik Prabhakaran

Monica E Calkins

Ryan Hopson

Chad Jackson

Jack Keefe

Marisa Riley

Frank D Mentch

Patrick Sleiman

Ragini Verma

Christos Davatzikos

Hakon Hakonarson

Ruben C Gur

Raquel E Gur

Affiliations

Soon will be listed here.

Abstract

The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.

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