Dynamic Mapping of Human Cortical Development During Childhood Through Early Adulthood

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2004 May 19

PMID 15148381

Citations 2201

Authors

Nitin Gogtay

Jay N Giedd

Leslie Lusk

Kiralee M Hayashi

Deanna Greenstein

A Catherine Vaituzis

Tom F Nugent 3rd

David H Herman

Liv S Clasen

Arthur W Toga

Judith L Rapoport

Paul M Thompson

Affiliations

Soon will be listed here.

Abstract

We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences. Thirteen healthy children for whom anatomic brain MRI scans were obtained every 2 years, for 8-10 years, were studied. By using models of the cortical surface and sulcal landmarks and a statistical model for gray matter density, human cortical development could be visualized across the age range in a spatiotemporally detailed time-lapse sequence. The resulting time-lapse "movies" reveal that (i) higher-order association cortices mature only after lower-order somatosensory and visual cortices, the functions of which they integrate, are developed, and (ii) phylogenetically older brain areas mature earlier than newer ones. Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism.

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