Hsp70 Inhibition Induces Myeloma Cell Death Via the Intracellular Accumulation of Immunoglobulin and the Generation of Proteotoxic Stress

Overview

Journal Cancer Lett

Specialty Oncology

Date 2013 Jul 27

PMID 23887058

Citations 22

Authors

Lei Zhang

Jacqueline J L Fok

Fabio Mirabella

Lauren I Aronson

Rosemary A Fryer

Paul Workman

Gareth J Morgan

Faith E Davies

Affiliations

Soon will be listed here.

Abstract

Multiple myeloma (MM) cells rely on protein homeostatic mechanisms for survival. These mechanisms could be therapeutically targeted via modulation of the heat shock response. We studied the roles of Hsp72 and Hsc70, and show that the two major cytoplasmic Hsp70s play a key role in regulating protein homeostasis and controlling multiple oncogenic pathways in MM, and their inhibition can lead to myeloma cell death. Our study provides further evidence that targeting Hsp70 represents a novel therapeutic approach which may be effective in the treatment of MM.

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