Evidence for Two Ca2(+)-mobilizing Purinoceptors on Rat Hepatocytes

Overview

Journal Biochem J

Specialty Biochemistry

Date 1990 Jul 15

PMID 2386488

Citations 30

Authors

C J Dixon

N M Woods

K S Cuthbertson

P H Cobbold

Affiliations

Soon will be listed here.

Abstract

Aequorin measurements of cytosolic free Ca2+ in single rat hepatocytes show that ADP and ATP, thought to act through the same P2Y purinoceptor, elicited very different responses in the majority of cells tested. ADP invariably induced transients of short duration (approx. 9 s), whereas ATP induced either similar transients or transients with a much longer duration (approx. 49 s). We explain this variability in terms of two separate purinoceptors on rat hepatocytes, one of which responds to either ATP or ADP to generate free-Ca2+ transients of short duration, and the other responds to ATP only, with transients of longer duration.

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