Emerging Applications of Conjugated Polymers in Molecular Imaging

Overview

Journal Phys Chem Chem Phys

Publisher Royal Society of Chemistry

Specialties Biophysics
Chemistry

Date 2013 Jul 18

PMID 23860904

Citations 8

Authors

Junwei Li

Jie Liu

Chen-Wei Wei

Bin Liu

Matthew ODonnell

Xiaohu Gao

Affiliations

Soon will be listed here.

Abstract

In recent years, conjugated polymers have attracted considerable attention from the imaging community as a new class of contrast agent due to their intriguing structural, chemical, and optical properties. Their size and emission wavelength tunability, brightness, photostability, and low toxicity have been demonstrated in a wide range of in vitro sensing and cellular imaging applications, and have just begun to show impact in in vivo settings. In this Perspective, we summarize recent advances in engineering conjugated polymers as imaging contrast agents, their emerging applications in molecular imaging (referred to as in vivo uses in this paper), as well as our perspectives on future research.

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References

Moon J, Mendez E, Kim Y, Kaur A . Conjugated polymer nanoparticles for small interfering RNA delivery. Chem Commun (Camb). 2011; 47(29):8370-2. DOI: 10.1039/c1cc10991j. View

Wu C, Chiu D . Highly fluorescent semiconducting polymer dots for biology and medicine. Angew Chem Int Ed Engl. 2013; 52(11):3086-109. PMC: 5616106. DOI: 10.1002/anie.201205133. View

Zrazhevskiy P, Gao X . Multifunctional Quantum Dots for Personalized Medicine. Nano Today. 2010; 4(5):414-428. PMC: 2757762. DOI: 10.1016/j.nantod.2009.07.004. View

Weissleder R . Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer. 2002; 2(1):11-8. DOI: 10.1038/nrc701. View

Weissleder R . A clearer vision for in vivo imaging. Nat Biotechnol. 2001; 19(4):316-7. DOI: 10.1038/86684. View

Li K, Qin W, Ding D, Tomczak N, Geng J, Liu R . Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci Rep. 2013; 3:1150. PMC: 3556677. DOI: 10.1038/srep01150. View

Cheng L, Yang K, Chen Q, Liu Z . Organic stealth nanoparticles for highly effective in vivo near-infrared photothermal therapy of cancer. ACS Nano. 2012; 6(6):5605-13. DOI: 10.1021/nn301539m. View

Weissleder R, Pittet M . Imaging in the era of molecular oncology. Nature. 2008; 452(7187):580-9. PMC: 2708079. DOI: 10.1038/nature06917. View

Xiong L, Shuhendler A, Rao J . Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging. Nat Commun. 2012; 3:1193. PMC: 3527090. DOI: 10.1038/ncomms2197. View

10.

Pecher J, Huber J, Winterhalder M, Zumbusch A, Mecking S . Tailor-made conjugated polymer nanoparticles for multicolor and multiphoton cell imaging. Biomacromolecules. 2010; 11(10):2776-80. DOI: 10.1021/bm100854a. View

11.

Ding D, Liu J, Feng G, Li K, Hu Y, Liu B . Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. Small. 2013; 9(18):3093-102. DOI: 10.1002/smll.201300171. View

12.

Choi H, Liu W, Misra P, Tanaka E, Zimmer J, Ipe B . Renal clearance of quantum dots. Nat Biotechnol. 2007; 25(10):1165-70. PMC: 2702539. DOI: 10.1038/nbt1340. View

13.

Ding D, Wang G, Liu J, Li K, Pu K, Hu Y . Hyperbranched conjugated polyelectrolyte for dual-modality fluorescence and magnetic resonance cancer imaging. Small. 2012; 8(22):3523-30. DOI: 10.1002/smll.201201216. View

14.

Duan X, Liu L, Feng F, Wang S . Cationic conjugated polymers for optical detection of DNA methylation, lesions, and single nucleotide polymorphisms. Acc Chem Res. 2009; 43(2):260-70. DOI: 10.1021/ar9001813. View

15.

Thomas 3rd S, Joly G, Swager T . Chemical sensors based on amplifying fluorescent conjugated polymers. Chem Rev. 2007; 107(4):1339-86. DOI: 10.1021/cr0501339. View

16.

Feng G, Ding D, Liu B . Fluorescence bioimaging with conjugated polyelectrolytes. Nanoscale. 2012; 4(20):6150-65. DOI: 10.1039/c2nr31392h. View

17.

Gao X, Yang L, Petros J, Marshall F, Simons J, Nie S . In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotechnol. 2005; 16(1):63-72. DOI: 10.1016/j.copbio.2004.11.003. View

18.

Nel A, Xia T, Madler L, Li N . Toxic potential of materials at the nanolevel. Science. 2006; 311(5761):622-7. DOI: 10.1126/science.1114397. View

19.

Ding D, Li K, Qin W, Zhan R, Hu Y, Liu J . Conjugated polymer amplified far-red/near-infrared fluorescence from nanoparticles with aggregation-induced emission characteristics for targeted in vivo imaging. Adv Healthc Mater. 2012; 2(3):500-7. DOI: 10.1002/adhm.201200243. View

20.

Liu Z, Davis C, Cai W, He L, Chen X, Dai H . Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci U S A. 2008; 105(5):1410-5. PMC: 2234157. DOI: 10.1073/pnas.0707654105. View