Photostable Fluorescent Organic Dots with Aggregation-induced Emission (AIE Dots) for Noninvasive Long-term Cell Tracing

Overview

Journal Sci Rep

Specialty Science

Date 2013 Jan 30

PMID 23359649

Citations 41

Authors

Kai Li

Wei Qin

Dan Ding

Nikodem Tomczak

Junlong Geng

Rongrong Liu

Jianzhao Liu

Xinhai Zhang

Hongwei Liu

Bin Liu

Ben Zhong Tang

Affiliations

Soon will be listed here.

Abstract

Long-term noninvasive cell tracing by fluorescent probes is of great importance to life science and biomedical engineering. For example, understanding genesis, development, invasion and metastasis of cancerous cells and monitoring tissue regeneration after stem cell transplantation require continual tracing of the biological processes by cytocompatible fluorescent probes over a long period of time. In this work, we successfully developed organic far-red/near-infrared dots with aggregation-induced emission (AIE dots) and demonstrated their utilities as long-term cell trackers. The high emission efficiency, large absorptivity, excellent biocompatibility, and strong photobleaching resistance of the AIE dots functionalized by cell penetrating peptides derived from transactivator of transcription proteins ensured outstanding long-term noninvasive in vitro and in vivo cell tracing. The organic AIE dots outperform their counterparts of inorganic quantum dots, opening a new avenue in the development of fluorescent probes for following biological processes such as carcinogenesis.

Citing Articles

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