Age- and Gender-related Changes in Ventricular Performance in Wild-type FVB/N Mice As Evaluated by Conventional and Vector Velocity Echocardiography Imaging: a Retrospective Study

Overview

Journal Ultrasound Med Biol

Specialty Radiology

Date 2013 Jun 25

PMID 23791351

Citations 13

Authors

Sheryl E Koch

Kevin J Haworth

Nathan Robbins

Margaret A Smith

Navneet Lather

Ahmad Anjak

Min Jiang

Priyanka Varma

W Keith Jones

Jack Rubinstein

Affiliations

Soon will be listed here.

Abstract

Detailed studies in animal models to assess the importance of aging animals in cardiovascular research are rather scarce. The increase in mouse models used to study cardiovascular disease makes the establishment of physiologic aging parameters in myocardial function in both male and female mice critical. Forty-four FVB/N mice were studied at multiple time points between the ages of 3 and 16 mo using high-frequency echocardiography. Our study found that there is an age-dependent decrease in several systolic and diastolic function parameters in male mice, but not in female mice. This study establishes the physiologic age- and gender-related changes in myocardial function that occur in mice and can be measured with echocardiography. We report baseline values for traditional echocardiography and advanced echocardiographic techniques to measure discrete changes in cardiac function in the commonly employed FVB/N strain.

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