A Magnetoplasmonic Imaging Agent for Copper(I) with Dual Response by MRI and Dark Field Microscopy

Overview

Journal ACS Nano

Publisher American Chemical Society

Specialty Biotechnology

Date 2013 Jun 11

PMID 23746216

Citations 4

Authors

Evan A Weitz

Cutler Lewandowski

Eric D Smolensky

Malgorzata Marjanska

Valerie C Pierre

Affiliations

Soon will be listed here.

Abstract

We present the design and synthesis of a responsive magnetoplasmonic assembly for copper(I) which allows monitoring of the concentration of the metal both in three dimensions by magnetic resonance imaging and with high spatial resolution by dark field microscopy. The probe consists of azide-functionalized iron oxide nanoparticles 11.6 nm in diameter and acetylene-terminated gold nanoparticles 44 nm in diameter that form three-dimensional networks of intermingled magnetic and plasmonic nanoparticles in the presence of copper. This aggregation results in a decrease in longitudinal relaxivity, and an initial increase followed by a sharp decrease in transverse relaxivity, a change observable both by T1- and T2-weighted images, concomitantly with a decrease of surface plasmon resonance intensity.

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Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe.

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