Autologous Pancreatic Islet Transplantation in Human Bone Marrow

Overview

Journal Diabetes

Specialty Endocrinology

Date 2013 Jun 5

PMID 23733196

Citations 43

Authors

Paola Maffi

Gianpaolo Balzano

Maurilio Ponzoni

Rita Nano

Valeria Sordi

Raffaella Melzi

Alessia Mercalli

Marina Scavini

Antonio Esposito

Jacopo Peccatori

Elisa Cantarelli

Carlo Messina

Massimo Bernardi

Alessandro Del Maschio

Carlo Staudacher

Claudio Doglioni

Fabio Ciceri

Antonio Secchi

Lorenzo Piemonti

Affiliations

Soon will be listed here.

Abstract

The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being ideal. We recently have shown in mice that the bone marrow (BM) may be a valid alternative to the liver, and here we report a pilot study to test feasibility and safety of BM as a site for islet transplantation in humans. Four patients who developed diabetes after total pancreatectomy were candidates for the autologous transplantation of pancreatic islet. Because the patients had contraindications for intraportal infusion, islets were infused in the BM. In all recipients, islets engrafted successfully as shown by measurable posttransplantation C-peptide levels and histopathological evidence of insulin-producing cells or molecular markers of endocrine tissue in BM biopsy samples analyzed during follow-up. Thus far, we have recorded no adverse events related to the infusion procedure or the presence of islets in the BM. Islet function was sustained for the maximum follow-up of 944 days. The encouraging results of this pilot study provide new perspectives in identifying alternative sites for islet infusion in patients with type 1 diabetes. Moreover, this is the first unequivocal example of successful engraftment of endocrine tissue in the BM in humans.

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