Genome-wide Approaches for Identifying Genetic Risk Factors for Osteoporosis

Overview

Journal Genome Med

Publisher Biomed Central

Specialty Genetics

Date 2013 Jun 5

PMID 23731620

Citations 14

Authors

Shuyan Wu

Yongjun Liu

Lei Zhang

Yingying Han

Yong Lin

Hong-Wen Deng

Affiliations

Soon will be listed here.

Abstract

Osteoporosis, the most common type of bone disease worldwide, is clinically characterized by low bone mineral density (BMD) and increased susceptibility to fracture. Multiple genetic and environmental factors and gene-environment interactions have been implicated in its pathogenesis. Osteoporosis has strong genetic determination, with the heritability of BMD estimated to be as high as 60%. More than 80 genes or genetic variants have been implicated in risk of osteoporosis by hypothesis-free genome-wide studies. However, these genes or genetic variants can only explain a small portion of BMD variation, suggesting that many other genes or genetic variants underlying osteoporosis risk await discovery. Here, we review recent progress in genome-wide studies of osteoporosis and discuss their implications for medicine and the major challenges in the field.

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