Rapid Phenotyping of Knockout Mice to Identify Genetic Determinants of Bone Strength

Overview

Journal J Endocrinol

Specialty Endocrinology

Date 2016 Aug 19

PMID 27535945

Citations 20

Authors

Bernard Freudenthal

John Logan

Peter I Croucher

Graham R Williams

J H Duncan Bassett

Affiliations

Soon will be listed here.

Abstract

The genetic determinants of osteoporosis remain poorly understood, and there is a large unmet need for new treatments in our ageing society. Thus, new approaches for gene discovery in skeletal disease are required to complement the current genome-wide association studies in human populations. The International Knockout Mouse Consortium (IKMC) and the International Mouse Phenotyping Consortium (IMPC) provide such an opportunity. The IKMC generates knockout mice representing each of the known protein-coding genes in C57BL/6 mice and, as part of the IMPC initiative, the Origins of Bone and Cartilage Disease project identifies mutants with significant outlier skeletal phenotypes. This initiative will add value to data from large human cohorts and provide a new understanding of bone and cartilage pathophysiology, ultimately leading to the identification of novel drug targets for the treatment of skeletal disease.

Citing Articles

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