» Articles » PMID: 23636598

Environmental Factors and Unhealthy Lifestyle Influence Oxidative Stress in Humans--an Overview

Overview
Publisher Springer
Date 2013 May 3
PMID 23636598
Citations 76
Authors
Affiliations
Soon will be listed here.
Abstract

Oxygen is the most essential molecule for life; since it is a strong oxidizing agent, it can aggravate the damage within the cell by a series of oxidative events including the generation of free radicals. Antioxidative agents are the only defense mechanism to neutralize these free radicals. Free radicals are not only generated internally in our body system but also trough external sources like environmental pollution, toxic metals, cigarette smoke, pesticides, etc., which add damage to our body system. Inhaling these toxic chemicals in the environment has become unavoidable in modern civilization. Antioxidants of plant origin with free radical scavenging properties could have great importance as therapeutic agents in several diseases caused by environmental pollution. This review summarizes the generation of reactive oxygen species and damage to cells by exposure to external factors, unhealthy lifestyle, and role of herbal plants in scavenging these reactive oxygen species.

Citing Articles

Joint Effects of Lifestyle Habits and Heavy Metals Exposure on Chronic Stress Among U.S. Adults: Insights from NHANES 2017-2018.

Ogundipe E, Obeng-Gyasi E J Xenobiot. 2025; 15(1.

PMID: 39846539 PMC: 11755626. DOI: 10.3390/jox15010007.


Yoga: As a Transformative Approach to Addressing Male Infertility and Enhancing Reproductive Health in Men: A Narrative Review.

Yadav A, Tiwari P, Dada R J Hum Reprod Sci. 2025; 17(4):224-231.

PMID: 39831098 PMC: 11741127. DOI: 10.4103/jhrs.jhrs_147_24.


Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil.

Castro M, Costa L, Salum K, Castro H, Ribeiro P, Costa W J Bras Pneumol. 2025; 50(6):e20240318.

PMID: 39813504 PMC: 11665288. DOI: 10.36416/1806-3756/e20240318.


Loneliness and Social Isolation with Risk of Incident Non-alcoholic Fatty Liver Disease, UK Biobank 2006 to 2022.

Miao Y, Kong X, Zhao B, Fang F, Chai J, Huang J Health Data Sci. 2025; 5:0220.

PMID: 39780850 PMC: 11704091. DOI: 10.34133/hds.0220.


Biological activities of Hypericum spectabile extract optimized using artificial neural network combined with genetic algorithm application.

Gurgen A, Sevindik M, Krupodorova T, Uysal I, Unal O BMC Biotechnol. 2024; 24(1):83.

PMID: 39468527 PMC: 11520853. DOI: 10.1186/s12896-024-00914-w.


References
1.
Yedjou C, Izevbigie E, Tchounwou P . Preclinical assessment of vernonia amygdalina leaf extracts as DNA damaging anti-cancer agent in the management of breast cancer. Int J Environ Res Public Health. 2009; 5(5):337-41. PMC: 3699992. DOI: 10.3390/ijerph5050337. View

2.
Talamini R, Polesel J, Gallus S, Dal Maso L, Zucchetto A, Negri E . Tobacco smoking, alcohol consumption and pancreatic cancer risk: a case-control study in Italy. Eur J Cancer. 2009; 46(2):370-6. DOI: 10.1016/j.ejca.2009.09.002. View

3.
Markus M, Morris B . Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging. 2008; 3(2):331-9. PMC: 2546476. View

4.
Eisner M, Balmes J, Katz P, Trupin L, Yelin E, Blanc P . Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease. Environ Health. 2005; 4(1):7. PMC: 1145187. DOI: 10.1186/1476-069X-4-7. View

5.
Sachdev S, Davies K . Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med. 2008; 44(2):215-23. DOI: 10.1016/j.freeradbiomed.2007.07.019. View