Genome-scale Studies of Aging: Challenges and Opportunities

Overview

Journal Curr Genomics

Publisher Bentham Science Publishers

Date 2013 May 2

PMID 23633910

Citations 9

Authors

Mark A McCormick

Brian K Kennedy

Affiliations

Soon will be listed here.

Abstract

Whole-genome studies involving a phenotype of interest are increasingly prevalent, in part due to a dramatic increase in speed at which many high throughput technologies can be performed coupled to simultaneous decreases in cost. This type of genome-scale methodology has been applied to the phenotype of lifespan, as well as to whole-transcriptome changes during the aging process or in mutants affecting aging. The value of high throughput discovery-based science in this field is clearly evident, but will it yield a true systems-level understanding of the aging process? Here we review some of this work to date, focusing on recent findings and the unanswered puzzles to which they point. In this context, we also discuss recent technological advances and some of the likely future directions that they portend.

Citing Articles

Decoding lifespan secrets: the role of the gonad in aging.

Pires da Silva A, Kelleher R, Reynoldson L Front Aging. 2024; 5:1380016.

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Pseudotime Analysis Reveals Exponential Trends in DNA Methylation Aging with Mortality Associated Timescales.

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Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated.

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Estimating network changes from lifespan measurements using a parsimonious gene network model of cellular aging.

Qin H BMC Bioinformatics. 2019; 20(1):599.

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goes through distinct metabolic phases during its replicative lifespan.

Leupold S, Hubmann G, Litsios A, Meinema A, Takhaveev V, Papagiannakis A Elife. 2019; 8.

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