Conservation and De Novo Acquisition of Dosage Compensation on Newly Evolved Sex Chromosomes in Drosophila

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2013 May 1

PMID 23630075

Citations 42

Authors

Artyom A Alekseyenko

Christopher E Ellison

Andrey A Gorchakov

Qi Zhou

Vera B Kaiser

Nick Toda

Zaak Walton

Shouyong Peng

Peter J Park

Doris Bachtrog

Mitzi I Kuroda

Affiliations

Soon will be listed here.

Abstract

Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.

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