Alpha 2.0

» Articles » PMID: 23543659

Relationships Between Serum Adiponectin and Bone Density, Adiposity and Calcified Atherosclerotic Plaque in the African American-Diabetes Heart Study

Overview

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2013 Apr 2

PMID 23543659

Citations 16

Authors

Authors

Thomas C Register

Jasmin Divers

Donald W Bowden

J Jeffrey Carr

Leon Lenchik

Lynne E Wagenknecht

R Caresse Hightower

Jianzhao Xu

S Carrie Smith

Keith A Hruska

Carl D Langefeld

Barry I Freedman

Affiliations

Affiliations

Soon will be listed here.

Abstract

Context: Adiposity, bone mineral density (BMD), and calcified atherosclerotic plaque (CP) exhibit complex interrelationships that are not well understood. Adipokines vary in relation to changes in body composition and may play roles in regulation of BMD and risk of cardiovascular disease.

Objective: Our objective was to examine the relationship between serum adiponectin and quantitative computed tomography-derived measures of volumetric BMD (vBMD) in thoracic and lumbar vertebrae, adipose tissue volumes, and CP in coronary, carotid, and infrarenal aortoiliac arteries. Generalized linear models were fitted to test for associations between adiponectin and measured phenotypes.

Participants: A total of 479 unrelated African Americans with type 2 diabetes, 57% female with a mean ± SD (median) age of 55.6 ± 9.5 (55.0) years and diabetes duration of 10.3 ± 8.2 (8.0) years.

Results: Serum adiponectin was 8.26 ± 7.41 (6.10) μg/mL, coronary artery CP mass score was 280 ± 634 (14), carotid artery CP was 47 ± 133 (0), and aortoiliac CP was 1616 ± 2864 (319). Women had significantly higher body mass index and serum adiponectin and lower coronary and carotid artery calcium than males (all P < .05). Before and after adjusting for age, sex, body mass index, mean arterial pressure, smoking status, hemoglobin A1c, thiazolidinedione use, and low-density lipoprotein-cholesterol, adiponectin was inversely associated with thoracic and lumbar vertebral vBMD [parameter estimates (PEs) of -0.06 and -0.021, respectively; both P < .0005], visceral adipose tissue (PE -0.02; P < 0.0001), and C-reactive protein (PE -0.07; P < .0001) and positively associated with intermuscular adipose tissue (PE 0.01; P = .03). After covariate adjustment, significant associations were not observed between adiponectin and CP in any vascular bed (P > .1).

Conclusion: Serum adiponectin levels were inversely associated with cross-sectional measures of thoracic and lumbar vertebral vBMD, inflammation, and visceral adiposity in African Americans but not with vascular CP after adjustment for covariates. The data support a regulatory/signaling role for adiponectin in the modulation of bone density.

Citing Articles

Association between a body shape index and cognitive impairment among US older adults aged 40 years and above from a cross-sectional survey of the NHANES 2011-2014.

Chen Y, Ding Y, Jin S, Zhang Y Front Endocrinol (Lausanne). 2024; 15:1411701.

PMID: 39377074 PMC: 11456444. DOI: 10.3389/fendo.2024.1411701.

Glucagon-like Peptide-1 Receptor Agonists and Diabetic Osteopathy: Another Positive Effect of Incretines? A 12 Months Longitudinal Study.

Al Refaie A, Baldassini L, Mondillo C, Ceccarelli E, Tarquini R, Gennari L Calcif Tissue Int. 2024; 115(2):160-168.

PMID: 38864922 PMC: 11246279. DOI: 10.1007/s00223-024-01240-1.

Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling.

Flores-Opazo M, Kopinke D, Helmbacher F, Fernandez-Verdejo R, Tunon-Suarez M, Lynch G Mol Aspects Med. 2024; 97:101277.

PMID: 38788527 PMC: 11692456. DOI: 10.1016/j.mam.2024.101277.

Obesity and Skeletal Fragility.

Chen R, Armamento-Villareal R J Clin Endocrinol Metab. 2023; 109(2):e466-e477.

PMID: 37440585 PMC: 10795939. DOI: 10.1210/clinem/dgad415.

Biochemical Markers of Bone Fragility in Patients with Diabetes. A Narrative Review by the IOF and the ECTS.

Meier C, Eastell R, Pierroz D, Lane N, Al-Daghri N, Suzuki A J Clin Endocrinol Metab. 2023; .

PMID: 37155585 PMC: 10505554. DOI: 10.1210/clinem/dgad255.

References

1.

Ukkola O, Santaniemi M . Adiponectin: a link between excess adiposity and associated comorbidities?. J Mol Med (Berl). 2002; 80(11):696-702. DOI: 10.1007/s00109-002-0378-7. View

2.

Riera-Guardia N, Rothenbacher D . The effect of thiazolidinediones on adiponectin serum level: a meta-analysis. Diabetes Obes Metab. 2007; 10(5):367-75. DOI: 10.1111/j.1463-1326.2007.00755.x. View

3.

Jurimae J, Rembel K, Jurimae T, Rehand M . Adiponectin is associated with bone mineral density in perimenopausal women. Horm Metab Res. 2005; 37(5):297-302. DOI: 10.1055/s-2005-861483. View

4.

Anuurad E, Chiem A, Pearson T, Berglund L . Metabolic syndrome components in african-americans and European-american patients and its relation to coronary artery disease. Am J Cardiol. 2007; 100(5):830-4. DOI: 10.1016/j.amjcard.2007.04.025. View

5.

Carr J, Register T, Hsu F, Lohman K, Lenchik L, Bowden D . Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study. Bone. 2007; 42(1):43-52. PMC: 2239236. DOI: 10.1016/j.bone.2007.08.023. View

6.

Levey A, Bosch J, Lewis J, Greene T, Rogers N, Roth D . A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130(6):461-70. DOI: 10.7326/0003-4819-130-6-199903160-00002. View

7.

Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T . Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem. 2006; 99(1):196-208. DOI: 10.1002/jcb.20890. View

8.

Yokota T, Meka C, Medina K, Igarashi H, Comp P, Takahashi M . Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest. 2002; 109(10):1303-10. PMC: 2447671. DOI: 10.1172/JCI14506. View

9.

Li F, Cheng K, Lam K, Vanhoutte P, Xu A . Cross-talk between adipose tissue and vasculature: role of adiponectin. Acta Physiol (Oxf). 2010; 203(1):167-80. DOI: 10.1111/j.1748-1716.2010.02216.x. View

10.

Lenchik L, Register T, Hsu F, Lohman K, Nicklas B, Freedman B . Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone. 2003; 33(4):646-51. DOI: 10.1016/s8756-3282(03)00237-0. View

11.

Wallis G, Rash B, Sykes B, Bonaventure J, Maroteaux P, Zabel B . Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia. J Med Genet. 1996; 33(6):450-7. PMC: 1050629. DOI: 10.1136/jmg.33.6.450. View

12.

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999; 257(1):79-83. DOI: 10.1006/bbrc.1999.0255. View

13.

Divers J, Wagenknecht L, Bowden D, Carr J, Hightower R, Ding J . Regional adipose tissue associations with calcified atherosclerotic plaque: African American-diabetes heart study. Obesity (Silver Spring). 2010; 18(10):2004-9. PMC: 2920341. DOI: 10.1038/oby.2010.30. View

14.

Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K . PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001; 50(9):2094-9. DOI: 10.2337/diabetes.50.9.2094. View

15.

Luo X, Zhao L, Yuan L, Wang M, Xie H, Liao E . Development of arterial calcification in adiponectin-deficient mice: adiponectin regulates arterial calcification. J Bone Miner Res. 2009; 24(8):1461-8. DOI: 10.1359/jbmr.090227. View

16.

Williams G, Wang Y, Callon K, Watson M, Lin J, Lam J . In vitro and in vivo effects of adiponectin on bone. Endocrinology. 2009; 150(8):3603-10. DOI: 10.1210/en.2008-1639. View

17.

Funahashi T, Nakamura T, Shimomura I, Maeda K, Kuriyama H, Takahashi M . Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern Med. 1999; 38(2):202-6. DOI: 10.2169/internalmedicine.38.202. View

18.

Warman M, Abbott M, Apte S, Hefferon T, McIntosh I, Cohn D . A type X collagen mutation causes Schmid metaphyseal chondrodysplasia. Nat Genet. 1993; 5(1):79-82. DOI: 10.1038/ng0993-79. View

19.

Kontogianni M, Dafni U, Routsias J, Skopouli F . Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res. 2004; 19(4):546-51. DOI: 10.1359/JBMR.040107. View

20.

Divers J, Register T, Langefeld C, Wagenknecht L, Bowden D, Carr J . Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011; 26(7):1554-60. PMC: 4341826. DOI: 10.1002/jbmr.389. View