Micro-compartment Specific T2* Relaxation in the Brain

Overview

Journal Neuroimage

Specialty Radiology

Date 2013 Mar 27

PMID 23528924

Citations 85

Authors

Pascal Sati

Peter van Gelderen

Afonso C Silva

Daniel S Reich

Hellmut Merkle

Jacco A de Zwart

Jeff H Duyn

Affiliations

Soon will be listed here.

Abstract

MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a signal dependence on the orientation of white matter (WM) fiber bundles relative to the magnetic field. In addition, study of the NMR relaxation properties of this signal has indicated contributions from compartmentalized water environments inside and outside the myelin sheath that may be separable. Here we further investigated the effects of water compartmentalization on the MRI signal with the goal of extracting compartment-specific information. By comparing MRI measurements of human and marmoset brain at 7T with magnetic field modeling, we show that: (1) water between the myelin lipid bilayers, in the axonal, and in the interstitial space each experience characteristic magnetic field effects that depend on fiber orientation (2) these field effects result in characteristic relaxation properties and frequency shifts for these compartments; and (3) compartmental contributions may be separated by multi-component fitting of the MRI signal relaxation (i.e. decay) curve. We further show the potential application of these findings to the direct mapping of myelin content and assessment of WM fiber integrity with high field MRI.

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