Fishing for Mammalian Paradigms in the Teleost Immune System

Overview

Journal Nat Immunol

Date 2013 Mar 20

PMID 23507645

Citations 77

Authors

J Oriol Sunyer

Affiliations

Soon will be listed here.

Abstract

Recent years have witnessed a renaissance in the study of fish immune systems. Such studies have greatly expanded the knowledge of the evolution and diversification of vertebrate immune systems. Several findings in those studies have overturned old paradigms about the immune system and led to the discovery of novel aspects of mammalian immunity. Here I focus on how findings pertaining to immunity in teleost (bony) fish have led to major new insights about mammalian B cell function in innate and adaptive immunity. Additionally, I illustrate how the discovery of the most ancient mucosal immunoglobulin described thus far will help resolve unsettled paradigms of mammalian mucosal immunity.

Citing Articles

Advances and Challenges in Vaccine Development: Immunological Insights and Future Perspectives.

Miryala K, Swain B Vaccines (Basel). 2025; 13(2).

PMID: 40006748 PMC: 11861604. DOI: 10.3390/vaccines13020202.

Navigating Fish Immunity: Focus on Mucosal Immunity and the Evolving Landscape of Mucosal Vaccines.

Hopo M, Mabrok M, Abu-Elala N, Yu Y Biology (Basel). 2025; 13(12.

PMID: 39765647 PMC: 11727089. DOI: 10.3390/biology13120980.

Identification of Single-Nucleotide Polymorphisms in Differentially Expressed Genes Favoring Soybean Meal Tolerance in Higher-Growth Zebrafish (Danio rerio).

Ulloa P, Jilberto F, Lam N, Rincon G, Valenzuela L, Cordova-Alarcon V Mar Biotechnol (NY). 2024; 26(4):754-765.

PMID: 38958822 DOI: 10.1007/s10126-024-10343-7.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity.

Hu C, Zhang N, Hong Y, Tie R, Fan D, Lin A Elife. 2024; 13.

PMID: 38497789 PMC: 10948150. DOI: 10.7554/eLife.92424.

DNA methylation regulates B cell activation via repressing Pax5 expression in teleost.

Shi Y, Zhu Z, Chen Q, Chen X Front Immunol. 2024; 15:1363426.

PMID: 38404580 PMC: 10884147. DOI: 10.3389/fimmu.2024.1363426.

References

Ehrenstein M, Notley C . The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol. 2010; 10(11):778-86. DOI: 10.1038/nri2849. View

Henson P . Dampening inflammation. Nat Immunol. 2005; 6(12):1179-81. DOI: 10.1038/ni1205-1179. View

Steinman R, Turley S, Mellman I, Inaba K . The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med. 2000; 191(3):411-6. PMC: 2195815. DOI: 10.1084/jem.191.3.411. View

Edholm E, Bengten E, Wilson M . Insights into the function of IgD. Dev Comp Immunol. 2011; 35(12):1309-16. DOI: 10.1016/j.dci.2011.03.002. View

Hayakawa K, Asano M, Shinton S, Gui M, Allman D, Stewart C . Positive selection of natural autoreactive B cells. Science. 1999; 285(5424):113-6. DOI: 10.1126/science.285.5424.113. View

Solem S, Stenvik J . Antibody repertoire development in teleosts--a review with emphasis on salmonids and Gadus morhua L. Dev Comp Immunol. 2005; 30(1-2):57-76. DOI: 10.1016/j.dci.2005.06.007. View

Ye J, Bromage E, Kaattari S . The strength of B cell interaction with antigen determines the degree of IgM polymerization. J Immunol. 2009; 184(2):844-50. DOI: 10.4049/jimmunol.0902364. View

Kaattari S, Evans D, Klemer J . Varied redox forms of teleost IgM: an alternative to isotypic diversity?. Immunol Rev. 1999; 166:133-42. DOI: 10.1111/j.1600-065x.1998.tb01258.x. View

Li J, Barreda D, Zhang Y, Boshra H, Gelman A, LaPatra S . B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nat Immunol. 2006; 7(10):1116-24. DOI: 10.1038/ni1389. View

10.

Morris D, Rothstein T . Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes. J Exp Med. 1993; 177(3):857-61. PMC: 2190944. DOI: 10.1084/jem.177.3.857. View

11.

Gil-Cruz C, Bobat S, Marshall J, Kingsley R, Ross E, Henderson I . The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response. Proc Natl Acad Sci U S A. 2009; 106(24):9803-8. PMC: 2701014. DOI: 10.1073/pnas.0812431106. View

12.

Baumgarth N . The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol. 2010; 11(1):34-46. DOI: 10.1038/nri2901. View

13.

Haas K, Poe J, Steeber D, Tedder T . B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity. 2005; 23(1):7-18. DOI: 10.1016/j.immuni.2005.04.011. View

14.

Kantor A, Herzenberg L . Layered evolution in the immune system. A model for the ontogeny and development of multiple lymphocyte lineages. Ann N Y Acad Sci. 1992; 651:1-9. DOI: 10.1111/j.1749-6632.1992.tb24588.x. View

15.

Suzuki K, Ha S, Tsuji M, Fagarasan S . Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut. Semin Immunol. 2006; 19(2):127-35. DOI: 10.1016/j.smim.2006.10.001. View

16.

Kanther M, Rawls J . Host-microbe interactions in the developing zebrafish. Curr Opin Immunol. 2010; 22(1):10-9. PMC: 3030977. DOI: 10.1016/j.coi.2010.01.006. View

17.

Magor B, Magor K . Evolution of effectors and receptors of innate immunity. Dev Comp Immunol. 2001; 25(8-9):651-82. DOI: 10.1016/s0145-305x(01)00029-5. View

18.

Ochando J, Homma C, Yang Y, Hidalgo A, Garin A, Tacke F . Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol. 2006; 7(6):652-62. DOI: 10.1038/ni1333. View

19.

Ramirez-Gomez F, Greene W, Rego K, Hansen J, Costa G, Kataria P . Discovery and characterization of secretory IgD in rainbow trout: secretory IgD is produced through a novel splicing mechanism. J Immunol. 2011; 188(3):1341-9. DOI: 10.4049/jimmunol.1101938. View

20.

Hoffmann J . Antifungal defense in Drosophila. Nat Immunol. 2007; 8(6):543-5. DOI: 10.1038/ni0607-543. View