Role for Compartmentalization in Nephron Progenitor Differentiation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2013 Mar 15

PMID 23487745

Citations 86

Authors

Aaron C Brown

Sree Deepthi Muthukrishnan

Justin A Guay

Derek C Adams

Dillon A Schafer

Jennifer L Fetting

Leif Oxburgh

Affiliations

Soon will be listed here.

Abstract

Embryonic nephron progenitor cells are segregated in molecularly distinct compartments of unknown function. Our study reveals an integral role for bone morphogenetic protein-SMAD in promoting transition of progenitors from the primitive Cbp/p300-interacting transactivator 1 expressing (CITED1+) compartment to the uniquely sine oculis-related homeobox 2 expressing (SIX2-only) compartment where they become inducible by wingless-type mouse mammary tumor virus integration site family member (WNT)/β-catenin signaling. Significantly, CITED1(+) cells are refractory to WNT/β-catenin induction. We propose a model in which the primitive CITED1(+) compartment is refractory to induction by WNT9b/β-catenin, ensuring maintenance of undifferentiated progenitor cells for future nephrogenesis. Bone morphogenetic protein 7-SMAD is then required for transition to a distinct compartment in which cells become inducible by WNT9b/β-catenin, allowing them to progress toward epithelialization.

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