Actin-binding Protein Alpha-actinin 4 (ACTN4) is a Transcriptional Co-activator of RelA/p65 Sub-unit of NF-kB

Overview

Journal Oncotarget

Specialty Oncology

Date 2013 Mar 14

PMID 23482348

Citations 26

Authors

Vasilisa Aksenova

Lidia Turoverova

Mikhail Khotin

Karl-Eric Magnusson

Eugene Tulchinsky

Gerry Melino

George P Pinaev

Nickolai Barlev

Dmitri Tentler

Affiliations

Soon will be listed here.

Abstract

ACTN4 is an actin-binding protein that participates in cytoskeleton organisation. It resides both in the cytoplasm and nucleus and physically associates with various transcription factors. Here, we describe an effect of ACTN4 expression on transcriptional activity of the RelA/p65 subunit of NF-kB. We demonstrate that ACTN4 enhances RelA/p65-dependant expression of c-fos, MMP-3 and MMP-1 genes, but it does not affect TNC, ICAM1 and FN1 expression. Importantly, actin-binding domains of ACTN4 are not critical for the nuclear translocation and co-activation of RelA/p65- dependent transcription. Collectively, our data suggest that in the nucleus, ACTN4 functions as a selective transcriptional co-activator of RelA/p65.

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