NDM-8 Metallo-β-lactamase in a Multidrug-resistant Escherichia Coli Strain Isolated in Nepal

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2013 Mar 6

PMID 23459485

Citations 33

Authors

Tatsuya Tada

Tohru Miyoshi-Akiyama

Rajan K Dahal

Manoj K Sah

Hiroshi Ohara

Teruo Kirikae

Bharat M Pokhrel

Affiliations

Soon will be listed here.

Abstract

A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.

Citing Articles

Multi-drug Resistance, β-Lactamases Production, and Coexistence of and in Clinical Isolates From a Referral Hospital in Kathmandu, Nepal.

Bhusal B, Yadav B, Dawadi P, Rijal K, Ghimire P, Banjara M Microbiol Insights. 2023; 16:11786361231152220.

PMID: 36741474 PMC: 9893399. DOI: 10.1177/11786361231152220.

Detection of NDM Variants ( , , ) from Carbapenem-Resistant and : First Report from Nepal.

Thapa A, Upreti M, Bimali N, Shrestha B, Sah A, Nepal K Infect Drug Resist. 2022; 15:4419-4434.

PMID: 35983298 PMC: 9379106. DOI: 10.2147/IDR.S369934.

NDM-5-Producing Co-Harboring Gene in Companion Animals in China.

Kuang X, Yang R, Ye X, Sun J, Liao X, Liu Y Animals (Basel). 2022; 12(10).

PMID: 35625156 PMC: 9137672. DOI: 10.3390/ani12101310.

Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants.

Li X, Zhao D, Li W, Sun J, Zhang X Int J Mol Sci. 2022; 23(1).

PMID: 35008622 PMC: 8745225. DOI: 10.3390/ijms23010197.

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.

Bahr G, Gonzalez L, Vila A Chem Rev. 2021; 121(13):7957-8094.

PMID: 34129337 PMC: 9062786. DOI: 10.1021/acs.chemrev.1c00138.

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