Genotype-phenotype Correlation of β-lactamase-producing Uropathogenic Escherichia Coli (UPEC) Strains from Bangladesh

Overview

Journal Sci Rep

Specialty Science

Date 2020 Sep 5

PMID 32883963

Citations 7

Authors

Maqsud Hossain

Tahmina Tabassum

Aura Rahman

Arman Hossain

Tamanna Afroze

Abdul Mueed Ibne Momen

Abdus Sadique

Mrinmoy Sarker

Fariza Shams

Ahmed Ishtiaque

Abdul Khaleque

Munirul Alam

Anwar Huq

Gias U Ahsan

Rita R Colwell

Affiliations

Soon will be listed here.

Abstract

Escherichia coli is a pathogen commonly encountered in clinical laboratories, and is capable of causing a variety of diseases, both within the intestinal tract (intestinal pathogenic strains) and outside (extraintestinal pathogenic E. coli, or ExPEC). It is associated with urinary tract infections (UTIs), one of the most common infectious diseases in the world. This report represents the first comparative analysis of the draft genome sequences of 11 uropathogenic E. coli (UPEC) strains isolated from two tertiary hospitals located in Dhaka and Sylhet, Bangladesh, and is focused on comparing their genomic characteristics to each other and to other available UPEC strains. Multilocus sequence typing (MLST) confirmed the strains belong to ST59, ST131, ST219, ST361, ST410, ST448 and ST4204, with one of the isolates classified as a previously undocumented ST. De novo identification of the antibiotic resistance genes bla, bla, bla and bla was determined, and phenotypic-genotypic analysis of virulence revealed significant heterogeneity within UPEC phylogroups.

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