Bioavailability of Phytochemicals and Its Enhancement by Drug Delivery Systems

Overview

Journal Cancer Lett

Specialty Oncology

Date 2013 Feb 26

PMID 23435377

Citations 99

Authors

Farrukh Aqil

Radha Munagala

Jeyaprakash Jeyabalan

Manicka V Vadhanam

Affiliations

Soon will be listed here.

Abstract

Issues of poor oral bioavailability of cancer chemopreventives have hindered progress in cancer prevention. Novel delivery systems that modulate the pharmacokinetics of existing drugs, such as nanoparticles, cyclodextrins, niosomes, liposomes and implants, could be used to enhance the delivery of chemopreventive agents to target sites. The development of new approaches in prevention and treatment of cancer could encompass new delivery systems for approved and newly investigated compounds. In this review, we discuss some of the delivery approaches that have already made an impact by either delivering a drug to target tissue or increasing its bioavailability by many fold.

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