Bacterial Small RNA-based Negative Regulation: Hfq and Its Accomplices

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2013 Jan 31

PMID 23362267

Citations 160

Authors

Nicholas De Lay

Daniel J Schu

Susan Gottesman

Affiliations

Soon will be listed here.

Abstract

A large group of bacterial small regulatory RNAs (sRNAs) use the Hfq chaperone to mediate pairing with and regulation of mRNAs. Recent findings help to clarify how Hfq acts and highlight the role of the endonuclease RNase E and its associated proteins (the degradosome) in negative regulation by these sRNAs. sRNAs frequently uncouple transcription and translation by blocking ribosome access to the mRNA, allowing other proteins access to the mRNA. As more examples of sRNA-mediated regulation are studied, more variations on how Hfq, RNase E, and other proteins collaborate to bring about sRNA-based regulation are being found.

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