Metastasis Suppressor Genes

Overview

Journal Histol Histopathol

Specialties Anatomy & Histology
Pathology

Date 2013 Jan 26

PMID 23348381

Citations 17

Authors

Jinchun Yan

Qin Yang

Qihong Huang

Affiliations

Soon will be listed here.

Abstract

Metastasis is a major cause of cancer mortality. Metastasis is a complex process that requires the regulation of both metastasis-promoting and metastasis suppressor genes. The discovery of metastasis suppressor genes contributes significantly to our understanding of metastasis mechanisms and provides prognostic markers and therapeutic targets in clinical cancer management. In this review, we summarize the methods that have been used to identify metastasis suppressors and the potential clinical impact of these genes.

Citing Articles

Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer.

Supuramanian S, Dsa S, Harihar S Explor Target Antitumor Ther. 2023; 4(5):912-932.

PMID: 37970212 PMC: 10645471. DOI: 10.37349/etat.2023.00173.

Cancer resistance via the downregulation of the tumor suppressors and expressions: therapeutic implications.

Moghaddam M, Vivarelli S, Falzone L, Libra M, Bonavida B Explor Target Antitumor Ther. 2023; 4(2):170-207.

PMID: 37205308 PMC: 10185445. DOI: 10.37349/etat.2023.00128.

MicroRNA-1246 suppresses the metastasis of breast cancer cells by targeting the DYRK1A/PGRN axis to prevent the epithelial-mesenchymal transition.

Wang P, Chen W, Zhang Y, Zhong Q, Li Z, Wang Y Mol Biol Rep. 2022; 49(4):2711-2721.

PMID: 35059968 DOI: 10.1007/s11033-021-07080-8.

Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1.

Ordas L, Costa L, Lozano A, Chevillard C, Calovoulos A, Kantar D Cells. 2021; 10(6).

PMID: 34207462 PMC: 8234748. DOI: 10.3390/cells10061545.

Activation of Nm23-H1 to suppress breast cancer metastasis via redox regulation.

Kim B, Lee K Exp Mol Med. 2021; 53(3):346-357.

PMID: 33753879 PMC: 8080780. DOI: 10.1038/s12276-021-00575-1.

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