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Metastasis Suppressors Alter the Signal Transduction of Cancer Cells

Overview
Journal Nat Rev Cancer
Specialty Oncology
Date 2003 Jan 2
PMID 12509767
Citations 202
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Abstract

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?

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