MicroRNA Dysregulation in Multiple Sclerosis

Overview

Journal Front Genet

Date 2013 Jan 25

PMID 23346094

Citations 47

Authors

Omar de Faria Jr

Craig S Moore

Timothy E Kennedy

Jack P Antel

Amit Bar-Or

Ajit S Dhaunchak

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) demyelination and axonal degeneration. Although the cause of MS is still unknown, it is widely accepted that novel drug targets need to focus on both decreasing inflammation and promoting CNS repair. In MS and experimental autoimmune encephalomyelitis, non-coding small microRNAs (miRNAs) are dysregulated in the immune system and CNS. Since individual miRNAs are able to down-regulate multiple targeted mRNA transcripts, even minor changes in miRNA expression may lead to significant alterations in gene expression. Herein, we review miRNA signatures reported in CNS tissue and immune cells of MS patients and consider how altered miRNA expression may influence MS pathology.

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