A CAMP-response Element Binding Protein-induced MicroRNA Regulates Neuronal Morphogenesis

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2005 Nov 2

PMID 16260724

Citations 444

Authors

Ngan Vo

Matthew E Klein

Olga Varlamova

David M Keller

Tadashi Yamamoto

Richard H Goodman

Soren Impey

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA transcripts. Although the spatial and temporal patterning of miRNA expression is tightly controlled, little is known about signals that induce their expression nor mechanisms of their transcriptional regulation. Furthermore, few miRNA targets have been validated experimentally. The miRNA, miR132, was identified through a genome-wide screen as a target of the transcription factor, cAMP-response element binding protein (CREB). miR132 is enriched in neurons and, like many neuronal CREB targets, is highly induced by neurotrophins. Expression of miR132 in cortical neurons induced neurite outgrowth. Conversely, inhibition of miR132 function attenuated neuronal outgrowth. We provide evidence that miR132 regulates neuronal morphogenesis by decreasing levels of the GTPase-activating protein, p250GAP. These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues.

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