Release and Toxicity of Dental Resin Composite

Overview

Journal Toxicol Int

Date 2013 Jan 8

PMID 23293458

Citations 52

Authors

Saurabh K Gupta

Payal Saxena

Vandana A Pant

Aditya B Pant

Affiliations

Soon will be listed here.

Abstract

Dental resin composite that are tooth-colored materials have been considered as possible substitutes to mercury-containing silver amalgam filling. Despite the fact that dental resin composites have improved their physico-chemical properties, the concern for its intrinsic toxicity remains high. Some components of restorative composite resins are released in the oral environment initially during polymerization reaction and later due to degradation of the material. In vitro and in vivo studies have clearly identified that these components of restorative composite resins are toxic. But there is a large gap between the results published by research laboratories and clinical reports. The objective of this manuscript was to review the literature on release phenomenon as well as in vitro and in vivo toxicity of dental resin composite. Interpretation made from the recent data was also outlined.

Citing Articles

Toxicity of resin-matrix composites in a dental clinical setting.

Cordeiro M, Souza J, Gomes A, Correia P, Fidalgo-Pereira R Odontology. 2025; .

PMID: 40088310 DOI: 10.1007/s10266-025-01055-y.

Dimensional Accuracy of Different Three-Dimensional Printing Models as a Function of Varying the Printing Parameters.

Arnold C, Riss L, Hey J, Schweyen R Materials (Basel). 2024; 17(14).

PMID: 39063907 PMC: 11279353. DOI: 10.3390/ma17143616.

The application of hydrogels for enamel remineralization.

Liao J, Qiu J, Lin Y, Li Z Heliyon. 2024; 10(13):e33574.

PMID: 39040369 PMC: 11261051. DOI: 10.1016/j.heliyon.2024.e33574.

Evaluation of dental pulp stem cells response to flowable nano-hybrid dental composites: A comparative analysis.

Rady D, Albar N, Khayat W, Khalil M, Raafat S, Ramadan M PLoS One. 2024; 19(5):e0303154.

PMID: 38739591 PMC: 11090312. DOI: 10.1371/journal.pone.0303154.

Cytotoxicity and genotoxicity of bioceramic root canal sealers compared to conventional resin-based sealer.

Radwanski M, Rozpedek-Kaminska W, Galita G, Siwecka N, Sokolowski J, Majsterek I Sci Rep. 2024; 14(1):4124.

PMID: 38374199 PMC: 10876547. DOI: 10.1038/s41598-024-54726-1.

References

Myers D, Hutz R . Current status of potential bisphenol toxicity in dentistry. Gen Dent. 2011; 59(4):262-5. View

Schmalz G . The biocompatibility of non-amalgam dental filling materials. Eur J Oral Sci. 1998; 106(2 Pt 2):696-706. DOI: 10.1046/j.0909-8836.1998.eos10602ii05.x. View

Reichl F, Seiss M, Kleinsasser N, Kehe K, Kunzelmann K, Thomas P . Distribution and excretion of BisGMA in guinea pigs. J Dent Res. 2008; 87(4):378-80. DOI: 10.1177/154405910808700401. View

Bouillaguet S, Shaw L, Gonzalez L, Wataha J, Krejci I . Long-term cytotoxicity of resin-based dental restorative materials. J Oral Rehabil. 2002; 29(1):7-13. DOI: 10.1046/j.1365-2842.2002.00804.x. View

Reichl F, Durner J, Kunzelmann K, Hickel R, Spahl W, Hume W . Biological clearance of TEGDMA in guinea pigs. Arch Toxicol. 2001; 75(1):22-7. DOI: 10.1007/s002040000159. View

Bergenholtz G . Evidence for bacterial causation of adverse pulpal responses in resin-based dental restorations. Crit Rev Oral Biol Med. 2001; 11(4):467-80. DOI: 10.1177/10454411000110040501. View

Hashimoto M, Ito S, Tay F, Svizero N, Sano H, Kaga M . Fluid movement across the resin-dentin interface during and after bonding. J Dent Res. 2004; 83(11):843-8. DOI: 10.1177/154405910408301104. View

Podgorski M . Structure-property relationship in new photo-cured dimethacrylate-based dental resins. Dent Mater. 2011; 28(4):398-409. DOI: 10.1016/j.dental.2011.11.013. View

Lu Y, Liu T, Li H, Pi G . Histological evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide on human pulp tissue. Int Endod J. 2008; 41(8):643-50. DOI: 10.1111/j.1365-2591.2008.01396.x. View

10.

Finer Y, Santerre J . The influence of resin chemistry on a dental composite's biodegradation. J Biomed Mater Res A. 2004; 69(2):233-46. DOI: 10.1002/jbm.a.30000. View

11.

Sigusch B, Pflaum T, Volpel A, Gretsch K, Hoy S, Watts D . Resin-composite cytotoxicity varies with shade and irradiance. Dent Mater. 2012; 28(3):312-9. DOI: 10.1016/j.dental.2011.12.007. View

12.

Geurtsen W . Biocompatibility of resin-modified filling materials. Crit Rev Oral Biol Med. 2000; 11(3):333-55. DOI: 10.1177/10454411000110030401. View

13.

Martins C, Leyhausen G, Geurtsen W, Volk J . Intracellular glutathione: a main factor in TEGDMA-induced cytotoxicity?. Dent Mater. 2012; 28(4):442-8. DOI: 10.1016/j.dental.2011.11.022. View

14.

Schweikl H, Schmalz G, Rackebrandt K . The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells. Mutat Res. 1998; 415(1-2):119-30. DOI: 10.1016/s1383-5718(98)00067-9. View

15.

Schweikl H, Hiller K, Eckhardt A, Bolay C, Spagnuolo G, Stempfl T . Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate. Biomaterials. 2008; 29(10):1377-87. DOI: 10.1016/j.biomaterials.2007.11.049. View

16.

Sideridou I, Achilias D, Spyroudi C, Karabela M . Water sorption characteristics of light-cured dental resins and composites based on Bis-EMA/PCDMA. Biomaterials. 2003; 25(2):367-76. DOI: 10.1016/s0142-9612(03)00529-5. View

17.

Chen C, Huang S . Enzymatic responses of human deciduous pulpal fibroblasts to dental restorative materials. J Biomed Mater Res. 2002; 60(3):452-7. DOI: 10.1002/jbm.1291. View

18.

Volk J, Engelmann J, Leyhausen G, Geurtsen W . Effects of three resin monomers on the cellular glutathione concentration of cultured human gingival fibroblasts. Dent Mater. 2005; 22(6):499-505. DOI: 10.1016/j.dental.2005.06.002. View

19.

Geurtsen W . Substances released from dental resin composites and glass ionomer cements. Eur J Oral Sci. 1998; 106(2 Pt 2):687-95. DOI: 10.1046/j.0909-8836.1998.eos10602ii04.x. View

20.

Van Landuyt K, Nawrot T, Geebelen B, De Munck J, Snauwaert J, Yoshihara K . How much do resin-based dental materials release? A meta-analytical approach. Dent Mater. 2011; 27(8):723-47. DOI: 10.1016/j.dental.2011.05.001. View