» Articles » PMID: 39040369

The Application of Hydrogels for Enamel Remineralization

Overview
Journal Heliyon
Specialty Social Sciences
Date 2024 Jul 23
PMID 39040369
Authors
Affiliations
Soon will be listed here.
Abstract

Enamel is composed of numerous uniformly wide, well-oriented hydroxyapatite crystals. It possesses an acellular structure that cannot be repaired after undergoing damage. Therefore, remineralization after enamel defects has become a focal point of research. Hydrogels, which are materials with three-dimensional structures derived from cross-linking polymers, have garnered significant attention in recent studies. Their exceptional properties make them valuable in the application of enamel remineralization. In this review, we summarize the structure and formation of enamel, present the design considerations of hydrogels for enamel remineralization, explore diverse hydrogels types in this context, and finally, shed light on the potential future applications in this field.

Citing Articles

Whitening Efficiency of Papain and Bromelain Gels in Removing Dental Stains.

Cuc S, Sarosi C, Petean I, Moldovan A, Bacali C, Man S Gels. 2025; 11(2).

PMID: 39996643 PMC: 11854626. DOI: 10.3390/gels11020100.

References
1.
Ruan Q, Moradian-Oldak J . Development of amelogenin-chitosan hydrogel for in vitro enamel regrowth with a dense interface. J Vis Exp. 2014; (89). PMC: 4214252. DOI: 10.3791/51606. View

2.
Le Norcy E, Kwak S, Wiedemann-Bidlack F, Beniash E, Yamakoshi Y, Simmer J . Potential role of the amelogenin N-terminus in the regulation of calcium phosphate formation in vitro. Cells Tissues Organs. 2011; 194(2-4):188-93. PMC: 3178076. DOI: 10.1159/000324827. View

3.
Li L, Mao C, Wang J, Xu X, Pan H, Deng Y . Bio-inspired enamel repair via Glu-directed assembly of apatite nanoparticles: an approach to biomaterials with optimal characteristics. Adv Mater. 2011; 23(40):4695-701. DOI: 10.1002/adma.201102773. View

4.
Suo H, Zhang D, Yin J, Qian J, Wu Z, Fu J . Interpenetrating polymer network hydrogels composed of chitosan and photocrosslinkable gelatin with enhanced mechanical properties for tissue engineering. Mater Sci Eng C Mater Biol Appl. 2018; 92:612-620. DOI: 10.1016/j.msec.2018.07.016. View

5.
Cai L, Liu S, Guo J, Jia Y . Polypeptide-based self-healing hydrogels: Design and biomedical applications. Acta Biomater. 2020; 113:84-100. DOI: 10.1016/j.actbio.2020.07.001. View