Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Mar 29

PMID 36986769

Authors

Ylenia Della Rocca

Enrico Matteo Traini

Francesca Diomede

Luigia Fonticoli

Oriana Trubiani

Alessia Paganelli

Jacopo Pizzicannella

Guya Diletta Marconi

Affiliations

Soon will be listed here.

Abstract

Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.

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