Effect of Neuropeptide Y on Cardiac Output, Its Distribution, Regional Blood Flow and Organ Vascular Resistances in the Pithed Rat

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1990 Feb 1

PMID 2328398

Citations 5

Authors

M R MacLean

C R Hiley

Affiliations

Soon will be listed here.

Abstract

1. The effects of neuropeptide Y on cardiac output, its distribution and organ vascular resistances were determined with tracer microspheres in pithed rats. 2. Neuropeptide Y increased blood pressure by increasing both cardiac output and total peripheral resistance. The increase in cardiac output was due to an increase in stroke volume as heart rate was not changed. Increased vascular resistance in the splenic, renal, testicular, epididymal, skeletal muscle, large intestinal and mesenteric vascular beds contributed to the increase in total peripheral resistance. Vasoconstriction was most pronounced in the mesenteric bed. 3. This study indicates that neuropeptide Y increases blood pressure by increasing cardiac output and total peripheral resistance. The increased cardiac output is possibly due to an increase in venous return, whilst the increased total peripheral resistance was due to regional vasoconstriction, particularly in the mesenteric bed.

Citing Articles

A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections.

Gutsol A, Blanco P, Samokhina S, Afanasiev S, Kennedy C, Popov S PLoS One. 2019; 14(5):e0216734.

PMID: 31112562 PMC: 6529011. DOI: 10.1371/journal.pone.0216734.

Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance.

Whittle B Br J Pharmacol. 1993; 110(1):3-17.

PMID: 8220892 PMC: 2175995. DOI: 10.1111/j.1476-5381.1993.tb13763.x.

Selective regional vasoconstriction underlying pressor effects of galanin in anaesthetized possums compared with cats.

Courtice G, Hales J, Potter E J Physiol. 1994; 481 ( Pt 2):439-45.

PMID: 7537817 PMC: 1155942. DOI: 10.1113/jphysiol.1994.sp020452.

Effect of neuropeptide Y on alpha 2-adrenoceptor-mediated cardiovascular responses in the pithed rat.

Vila E, Macrae I Br J Pharmacol. 1990; 100(4):840-2.

PMID: 2169943 PMC: 1917579. DOI: 10.1111/j.1476-5381.1990.tb14101.x.

Comparison of the effects of neuropeptide Y and noradrenaline on rat gastric mucosal blood flow and integrity.

Tepperman B, Whittle B Br J Pharmacol. 1991; 102(1):95-100.

PMID: 2043936 PMC: 1917909. DOI: 10.1111/j.1476-5381.1991.tb12138.x.

References

Tatemoto K . Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A. 1982; 79(18):5485-9. PMC: 346928. DOI: 10.1073/pnas.79.18.5485. View

Hock C, Passmore J, Levin J, Neiberger R . Angiotensin II and alpha-adrenergic control of the intrarenal circulation in hemorrhage. Circ Shock. 1982; 9(1):81-94. View

Lundberg J, Terenius L, Hokfelt T, Goldstein M . High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett. 1983; 42(2):167-72. DOI: 10.1016/0304-3940(83)90401-9. View

Lundberg J, Saria A, Anggard A, Hokfelt T, Terenius L . Neuropeptide Y and noradrenaline interaction in peripheral cardiovascular control. Clin Exp Hypertens A. 1984; 6(10-11):1961-72. DOI: 10.3109/10641968409046110. View

Dahlof C, Dahlof P, Lundberg J . Neuropeptide Y (NPY): enhancement of blood pressure increase upon alpha-adrenoceptor activation and direct pressor effects in pithed rats. Eur J Pharmacol. 1985; 109(2):289-92. DOI: 10.1016/0014-2999(85)90433-9. View

Pernow J, Saria A, Lundberg J . Mechanisms underlying pre- and postjunctional effects of neuropeptide Y in sympathetic vascular control. Acta Physiol Scand. 1986; 126(2):239-49. DOI: 10.1111/j.1748-1716.1986.tb07811.x. View

Morris M, Elliott J, Cain M, Kapoor V, West M, Chalmers J . Plasma neuropeptide y levels rise in patients undergoing exercise tests for the investigation of chest pain. Clin Exp Pharmacol Physiol. 1986; 13(5):437-40. DOI: 10.1111/j.1440-1681.1986.tb00923.x. View

Hiley C, Thomas G . Effects of alpha-adrenoceptor agonists on cardiac output and its regional distribution in the pithed rat. Br J Pharmacol. 1987; 90(1):61-70. PMC: 1917298. DOI: 10.1111/j.1476-5381.1987.tb16825.x. View

Daly R, Hieble J . Neuropeptide Y modulates adrenergic neurotransmission by an endothelium dependent mechanism. Eur J Pharmacol. 1987; 138(3):445-6. DOI: 10.1016/0014-2999(87)90486-9. View

10.

Minson R, McRitchie R, Chalmers J . Effects of neuropeptide Y on left ventricular function in the conscious rabbit. Clin Exp Pharmacol Physiol. 1987; 14(3):263-6. DOI: 10.1111/j.1440-1681.1987.tb00387.x. View

11.

MARKS E, Haass M . Neuropeptide Y is a potent vasoconstrictor and a cardiodepressant in rat. Am J Physiol. 1987; 253(5 Pt 2):H1234-9. DOI: 10.1152/ajpheart.1987.253.5.H1234. View

12.

Westfall T, Carpentier S, Chen X, Beinfeld M, Naes L, Meldrum M . Prejunctional and postjunctional effects of neuropeptide Y at the noradrenergic neuroeffector junction of the perfused mesenteric arterial bed of the rat. J Cardiovasc Pharmacol. 1987; 10(6):716-22. DOI: 10.1097/00005344-198712000-00016. View

13.

Revington M, McCloskey D, Potter E . Effects of neuropeptide Y on the pressor responses to phenylephrine and to activation of the sympathetic nervous system in anaesthetized rats. Clin Exp Pharmacol Physiol. 1987; 14(9):703-10. DOI: 10.1111/j.1440-1681.1987.tb01895.x. View

14.

Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y . A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988; 332(6163):411-5. DOI: 10.1038/332411a0. View

15.

MacLean M, Hiley C . Effect of artificial respiratory volume on the cardiovascular responses to an alpha 1- and an alpha 2-adrenoceptor agonist in the air-ventilated pithed rat. Br J Pharmacol. 1988; 93(4):781-90. PMC: 1853908. DOI: 10.1111/j.1476-5381.1988.tb11463.x. View

16.

MacLean M, Hiley C . Effects of enalapril on changes in cardiac output and organ vascular resistances induced by alpha 1- and alpha 2-adrenoceptor agonists in pithed normotensive rats. Br J Pharmacol. 1988; 94(2):449-62. PMC: 1853967. DOI: 10.1111/j.1476-5381.1988.tb11547.x. View

17.

Gardiner S, Bennett T, Compton A . Regional haemodynamic effects of neuropeptide Y, vasopressin and angiotensin II in conscious, unrestrained, Long Evans and Brattleboro rats. J Auton Nerv Syst. 1988; 24(1-2):15-27. DOI: 10.1016/0165-1838(88)90131-2. View

18.

Han S, Trapani A, Fok K, Westfall T, Knuepfer M . Effects of endothelin on regional hemodynamics in conscious rats. Eur J Pharmacol. 1989; 159(3):303-5. DOI: 10.1016/0014-2999(89)90162-3. View

19.

Gardiner S, Compton A, Bennett T . Regional hemodynamic effects of endothelin-1 in conscious, unrestrained, Wistar rats. J Cardiovasc Pharmacol. 1989; 13 Suppl 5:S202-4. DOI: 10.1097/00005344-198900135-00057. View

20.

MacLean M, Thomson M, Hiley C . Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine. Br J Pharmacol. 1989; 97(2):419-32. PMC: 1854522. DOI: 10.1111/j.1476-5381.1989.tb11969.x. View