Osteocyte Apoptosis

Overview

Journal Bone

Specialties Endocrinology
Orthopedics

Date 2012 Dec 15

PMID 23238124

Citations 86

Authors

Robert L Jilka

Brendon Noble

Robert S Weinstein

Affiliations

Soon will be listed here.

Abstract

Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other states where bone must be removed. This is accomplished by yet to be defined signals emanating from dying osteocytes, which stimulate neighboring viable osteocytes to produce osteoclastogenic cytokines. The osteocyte apoptosis caused by chronic glucocorticoid administration does not increase osteoclasts; however, it does negatively impact maintenance of bone hydration, vascularity, and strength.

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