Linking Abnormal Mitosis to the Acquisition of DNA Damage

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2012 Dec 12

PMID 23229895

Citations 111

Authors

Neil J Ganem

David Pellman

Affiliations

Soon will be listed here.

Abstract

Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote transformation. Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.

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