Limiting the Proliferation of Polyploid Cells

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2007 Nov 6

PMID 17981108

Citations 106

Authors

Neil J Ganem

David Pellman

Affiliations

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Abstract

Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid cells. Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells.

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