MEF Promotes Stemness in the Pathogenesis of Gliomas

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2012 Dec 11

PMID 23217424

Citations 28

Authors

Elena Bazzoli

Teodoro Pulvirenti

Moritz C Oberstadt

Fabiana Perna

Boyoung Wee

Nikolaus Schultz

Jason T Huse

Elena I Fomchenko

Francesca Voza

Viviane Tabar

Cameron W Brennan

Lisa M DeAngelis

Stephen D Nimer

Eric C Holland

Massimo Squatrito

Affiliations

Soon will be listed here.

Abstract

High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

Citing Articles

ELF4 was a prognostic biomarker and related to immune infiltrates in glioma.

Zhuang Z, Zhang C, Tan Y, Zhang J, Zhong C J Cancer. 2024; 15(15):5101-5117.

PMID: 39132148 PMC: 11310870. DOI: 10.7150/jca.96886.

Role of Non-coding RNAs in the Response of Glioblastoma to Temozolomide.

Goleij P, Pourali G, Raisi A, Ravaei F, Golestan S, Abed A Mol Neurobiol. 2024; 62(2):1726-1755.

PMID: 39023794 DOI: 10.1007/s12035-024-04316-z.

Patient-derived organoids recapitulate glioma-intrinsic immune program and progenitor populations of glioblastoma.

Watanabe F, Hollingsworth E, Bartley J, Wisehart L, Desai R, Hartlaub A PNAS Nexus. 2024; 3(2):pgae051.

PMID: 38384384 PMC: 10879747. DOI: 10.1093/pnasnexus/pgae051.

ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.

Xu A, Sun M, Li Z, Chu Y, Fang K, Zhang Y Acta Biochim Biophys Sin (Shanghai). 2023; 56(1):129-139.

PMID: 37674363 PMC: 10875363. DOI: 10.3724/abbs.2023225.

Long non-coding RNA in glioma: novel genetic players in temozolomide resistance.

Roh J, Im M, Kang J, Youn B, Kim W Anim Cells Syst (Seoul). 2023; 27(1):19-28.

PMID: 36819921 PMC: 9937017. DOI: 10.1080/19768354.2023.2175497.

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