Brain Tumour Stem Cells

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2006 May 26

PMID 16723989

Citations 445

Authors

Angelo L Vescovi

Rossella Galli

Brent A Reynolds

Affiliations

Soon will be listed here.

Abstract

The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

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