Re(de)fining the Dendritic Cell Lineage

Overview

Journal Nat Immunol

Date 2012 Nov 20

PMID 23160217

Citations 232

Authors

Ansuman T Satpathy

Xiaodi Wu

Jorn C Albring

Kenneth M Murphy

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DCs) are essential mediators of innate and adaptive immune responses. Study of these critical cells has been complicated by their similarity to other hematopoietic lineages, particularly monocytes and macrophages. Progress has been made in three critical areas of DC biology: the characterization of lineage-restricted progenitors in the bone marrow, the identification of cytokines and transcription factors required during differentiation, and the development of genetic tools for the visualization and depletion of DCs in vivo. Collectively, these advances have clarified the nature of the DC lineage and have provided novel insights into their function during health and disease.

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References

Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez R, Wang Y . Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science. 2010; 329(5993):849-53. PMC: 3732486. DOI: 10.1126/science.1188510. View

Iacobelli M, Wachsman W, McGuire K . Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J Immunol. 2000; 165(2):860-8. DOI: 10.4049/jimmunol.165.2.860. View

Traver D, Akashi K, Manz M, Merad M, Miyamoto T, Engleman E . Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science. 2000; 290(5499):2152-4. DOI: 10.1126/science.290.5499.2152. View

Sathe P, Pooley J, Vremec D, Mintern J, Jin J, Wu L . The acquisition of antigen cross-presentation function by newly formed dendritic cells. J Immunol. 2011; 186(9):5184-92. DOI: 10.4049/jimmunol.1002683. View

Hashimoto D, Miller J, Merad M . Dendritic cell and macrophage heterogeneity in vivo. Immunity. 2011; 35(3):323-35. PMC: 4520532. DOI: 10.1016/j.immuni.2011.09.007. View

Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K . Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity. 1997; 7(4):483-92. DOI: 10.1016/s1074-7613(00)80370-2. View

Schiavoni G, Mattei F, Sestili P, Borghi P, Venditti M, Morse 3rd H . ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med. 2002; 196(11):1415-25. PMC: 2194263. DOI: 10.1084/jem.20021263. View

Segura E, Valladeau-Guilemond J, Donnadieu M, Sastre-Garau X, Soumelis V, Amigorena S . Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med. 2012; 209(4):653-60. PMC: 3328358. DOI: 10.1084/jem.20111457. View

Wang H, Morse 3rd H . IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol Res. 2008; 43(1-3):109-17. PMC: 2803682. DOI: 10.1007/s12026-008-8055-8. View

10.

Romani N, Koide S, Crowley M, Livingstone A, Fathman C, Inaba K . Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med. 1989; 169(3):1169-78. PMC: 2189287. DOI: 10.1084/jem.169.3.1169. View

11.

Elpek K, Bellemare-Pelletier A, Malhotra D, Reynoso E, Lukacs-Kornek V, DeKruyff R . Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site. PLoS One. 2011; 6(8):e23921. PMC: 3158776. DOI: 10.1371/journal.pone.0023921. View

12.

Lewis K, Caton M, Bogunovic M, Greter M, Grajkowska L, Ng D . Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity. 2011; 35(5):780-91. PMC: 3225703. DOI: 10.1016/j.immuni.2011.08.013. View

13.

Grouard G, Rissoan M, Filgueira L, Durand I, Banchereau J, Liu Y . The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med. 1997; 185(6):1101-11. PMC: 2196227. DOI: 10.1084/jem.185.6.1101. View

14.

Geissmann F, Gordon S, Hume D, Mowat A, Randolph G . Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol. 2010; 10(6):453-60. PMC: 3032581. DOI: 10.1038/nri2784. View

15.

Scharton-Kersten T, Contursi C, Masumi A, Sher A, Ozato K . Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med. 1997; 186(9):1523-34. PMC: 2199126. DOI: 10.1084/jem.186.9.1523. View

16.

Edelson B, Kc W, Juang R, Kohyama M, Benoit L, Klekotka P . Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med. 2010; 207(4):823-36. PMC: 2856032. DOI: 10.1084/jem.20091627. View

17.

Zheng Y, Valdez P, Danilenko D, Hu Y, Sa S, Gong Q . Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008; 14(3):282-9. DOI: 10.1038/nm1720. View

18.

Banchereau J, Steinman R . Dendritic cells and the control of immunity. Nature. 1998; 392(6673):245-52. DOI: 10.1038/32588. View

19.

Tussiwand R, Lee W, Murphy T, Mashayekhi M, Kc W, Albring J . Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012; 490(7421):502-7. PMC: 3482832. DOI: 10.1038/nature11531. View

20.

Naik S, Metcalf D, Van Nieuwenhuijze A, Wicks I, Wu L, OKeeffe M . Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol. 2006; 7(6):663-71. DOI: 10.1038/ni1340. View