Recent Advances in Protein Prenyltransferases: Substrate Identification, Regulation, and Disease Interventions

Overview

Journal Curr Opin Chem Biol

Publisher Elsevier

Specialty Biochemistry

Date 2012 Nov 13

PMID 23141597

Citations 26

Authors

Elaina A Zverina

Corissa L Lamphear

Elia N Wright

Carol A Fierke

Affiliations

Soon will be listed here.

Abstract

Protein post-translational modifications increase the functional diversity of the proteome by covalently adding chemical moieties onto proteins thereby changing their activation state, cellular localization, interacting partners, and life cycle. Lipidation is one such modification that enables membrane association of naturally cytosolic proteins. Protein prenyltransferases irreversibly install isoprenoid units of varying length via a thioether linkage onto proteins that exert their cellular activity at membranes. Substrates of prenyltransferases are involved in countless signaling pathways and processes within the cell. Identification of new prenylation substrates, prenylation pathway regulators, and dynamic trafficking of prenylated proteins are all avenues of intense, ongoing research that are challenging, exciting, and have the potential to significantly advance the field in the near future.

Citing Articles

Updates on protein-prenylation and associated inherited retinopathies.

Ashok S, Ramachandra Rao S Front Ophthalmol (Lausanne). 2024; 4:1410874.

PMID: 39026984 PMC: 11254824. DOI: 10.3389/fopht.2024.1410874.

Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets.

Tate E, Soday L, de la Lastra A, Wang M, Lin H Nat Rev Cancer. 2024; 24(4):240-260.

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Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes.

Wouters F, Bogie J, Wullaert A, van der Hilst J J Clin Immunol. 2023; 44(1):8.

PMID: 38129719 DOI: 10.1007/s10875-023-01621-5.

Chemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides.

Colombano A, Dalponte L, DallAngelo S, Clemente C, Idress M, Ghazal A Angew Chem Int Ed Engl. 2023; 62(16):e202215979.

PMID: 36815722 PMC: 10946513. DOI: 10.1002/anie.202215979.

Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization.

Marchwicka A, Kaminska D, Monirialamdari M, Blazewska K, Gendaszewska-Darmach E Int J Mol Sci. 2022; 23(10).

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