Endothelial-astrocytic Interactions in Acute Liver Failure

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2012 Oct 27

PMID 23099995

Citations 9

Authors

A R Jayakumar

M D Norenberg

Affiliations

Soon will be listed here.

Abstract

Brain edema and the subsequent increase in intracranial pressure are major neurological complications of acute liver failure (ALF), and swelling of astrocytes (cytotoxic brain edema) is the most prominent neuropathological abnormality in ALF. Recent studies, however, have suggested the co-existence of cytotoxic and vasogenic mechanisms in the brain edema associated with ALF. This review 1) summarizes the nature of the brain edema in humans and experimental animals with ALF; 2) reviews in vitro studies supporting the presence of cytotoxic brain edema (cell swelling in cultured astrocytes); and 3) documents the role of brain endothelial cells in the development of astrocyte swelling/brain edema in ALF.

Citing Articles

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PMID: 39457515 PMC: 11504045. DOI: 10.3390/biomedicines12102202.

Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.

Yang H, You L, Wang Z, Yang L, Wang X, Wu W Redox Biol. 2024; 69:103019.

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Radiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus.

Yassine M, Hassan S, Sommer S, Yucel L, Bellert H, Hallenberger J Cells. 2023; 12(1).

PMID: 36611854 PMC: 9818790. DOI: 10.3390/cells12010061.

Hyperammonemia in Hepatic Encephalopathy.

Jayakumar A, Norenberg M J Clin Exp Hepatol. 2018; 8(3):272-280.

PMID: 30302044 PMC: 6175739. DOI: 10.1016/j.jceh.2018.06.007.

Blood-Brain Barrier Permeability Is Exacerbated in Experimental Model of Hepatic Encephalopathy via MMP-9 Activation and Downregulation of Tight Junction Proteins.

Dhanda S, Sandhir R Mol Neurobiol. 2017; 55(5):3642-3659.

PMID: 28523565 DOI: 10.1007/s12035-017-0521-7.

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