Regulation of Ligand-independent Notch Signal Through Intracellular Trafficking

Overview

Journal Commun Integr Biol

Specialty Biology

Date 2012 Oct 13

PMID 23060962

Citations 17

Authors

Kazuya Hori

Anindya Sen

Tom Kirchhausen

Spyros Artavanis-Tsakonas

Affiliations

Soon will be listed here.

Abstract

Notch signaling is an evolutionarily conserved mechanism that defines a key cell fate control mechanism in metazoans. Notch signaling relies on the surface interaction between the Notch receptor and membrane bound ligands in an apposing cell. In our recent study,(22) we uncover a non-canonical receptor activation path that relies on a ligand-independent, intracellular activation of the receptor as it travels through the endosomal compartments. We found that Notch receptor, targeted for degradation lysosomal degradation through multivesicular bodies (MVBs) is "diverted" toward activation upon mono-ubiquitination through a synergy between the ubiquitin ligase Deltex, the non-visual β-arrestin Kurtz and the ESCRT-III component Shrub. This activation path is not universal but appears to depend on the cellular context.

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