» Articles » PMID: 19460341

Notch Signaling: the Core Pathway and Its Posttranslational Regulation

Overview
Journal Dev Cell
Publisher Cell Press
Date 2009 May 23
PMID 19460341
Citations 378
Authors
Affiliations
Soon will be listed here.
Abstract

Notch signaling controls numerous cell-fate specification events in multicellular organisms, and dysregulated Notch signaling causes several diseases with underlying developmental defects. A key step in Notch receptor activation is its intramembrane proteolysis, which releases an intracellular fragment that participates directly in transcriptional regulation of nuclear target genes. Despite the apparent simplicity of this mechanism, a host of posttranslational processes regulate Notch activity during its synthesis and secretion, ligand-dependent activation at the surface, endocytic trafficking, and degradation. This review describes the core developmental logic of Notch signaling and how regulatory mechanisms tailor Notch pathway outputs to specific developmental scenarios.

Citing Articles

Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer.

Liu D, Liu L, Che X, Wu G Front Cell Dev Biol. 2025; 13:1525345.

PMID: 39911323 PMC: 11794808. DOI: 10.3389/fcell.2025.1525345.


Intricate relationship between cancer stemness, metastasis, and drug resistance.

Dakal T, Bhushan R, Xu C, Gadi B, Cameotra S, Yadav V MedComm (2020). 2024; 5(10):e710.

PMID: 39309691 PMC: 11416093. DOI: 10.1002/mco2.710.


Long Non-Coding RNAs in Drug Resistance of Gastric Cancer: Complex Mechanisms and Potential Clinical Applications.

Meng X, Bai X, Ke A, Li K, Lei Y, Ding S Biomolecules. 2024; 14(6).

PMID: 38927012 PMC: 11201466. DOI: 10.3390/biom14060608.


Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.

Kacker S, Parsad V, Singh N, Hordiichuk D, Alvarez S, Gohar M J Dev Biol. 2024; 12(2).

PMID: 38804432 PMC: 11130840. DOI: 10.3390/jdb12020012.


Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.

Verma D, Singh A, Singh J, Mutsuddi M, Mukherjee A Cell Mol Life Sci. 2024; 81(1):195.

PMID: 38653877 PMC: 11039529. DOI: 10.1007/s00018-024-05142-1.