Differential Gene and MicroRNA Expression Between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Oct 3

PMID 23028896

Citations 16

Authors

Karobi Moitra

Kate Im

Katy Limpert

Alexander Borsa

Julie Sawitzke

Rob Robey

Naoya Yuhki

Ram Savan

Da Wei Huang

Richard A Lempicki

Susan Bates

Michael Dean

Affiliations

Soon will be listed here.

Abstract

In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.

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