Control by a Hair's Breadth: the Role of MicroRNAs in the Skin

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2012 Sep 18

PMID 22983383

Citations 29

Authors

Matthew S Ning

Thomas Andl

Affiliations

Soon will be listed here.

Abstract

MicroRNAs have continued to attract enormous interest in the scientific community ever since their discovery. Their allure stems from their unique role in posttranscriptional gene expression control as well as their potential application as therapeutic targets in various disease pathologies. While much is known concerning their general biological function, such as their interaction with RNA-induced silencing complexes, many important questions still remain unanswered, especially regarding their functions in the skin. In this review, we summarize our current knowledge of the role of microRNAs in the skin in order to shine new light on our understanding of cutaneous biology and emphasize the significance of these small, single-stranded RNA molecules in the largest organ of the human body. Key events in epidermal and hair follicle biology, including differentiation, proliferation, and pigmentation, all involve microRNAs. We explore the role of microRNAs in several cutaneous processes, such as appendage formation, wound-healing, epithelial-mesenchymal transition, carcinogenesis, immune response, and aging. In addition, we discuss current trends in research and offer suggestions for future studies.

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References

Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H . A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer Res. 2011; 71(21):6836-47. PMC: 3206139. DOI: 10.1158/0008-5472.CAN-11-0846. View

Odar K, Bostjancic E, Gale N, Glavac D, Zidar N . Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. Histopathology. 2012; 61(2):257-65. DOI: 10.1111/j.1365-2559.2012.04242.x. View

Glud M, Manfe V, Biskup E, Holst L, Dirksen A, Hastrup N . MicroRNA miR-125b induces senescence in human melanoma cells. Melanoma Res. 2011; 21(3):253-6. DOI: 10.1097/CMR.0b013e328345333b. View

Tay Y, Kats L, Salmena L, Weiss D, Tan S, Ala U . Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011; 147(2):344-57. PMC: 3235920. DOI: 10.1016/j.cell.2011.09.029. View

Warnefors M, Eyre-Walker A . The accumulation of gene regulation through time. Genome Biol Evol. 2011; 3:667-73. PMC: 3157833. DOI: 10.1093/gbe/evr019. View

Smith-Vikos T, Slack F . MicroRNAs and their roles in aging. J Cell Sci. 2012; 125(Pt 1):7-17. PMC: 3269020. DOI: 10.1242/jcs.099200. View

Montecalvo A, Larregina A, Shufesky W, Stolz D, Sullivan M, Karlsson J . Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2011; 119(3):756-66. PMC: 3265200. DOI: 10.1182/blood-2011-02-338004. View

Sand M, Skrygan M, Georgas D, Arenz C, Gambichler T, Sand D . Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer. Mol Carcinog. 2011; 51(11):916-22. DOI: 10.1002/mc.20861. View

Lutz C, Moreira A . Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression. Wiley Interdiscip Rev RNA. 2011; 2(1):22-31. DOI: 10.1002/wrna.47. View

10.

Viswanathan S, Daley G, Gregory R . Selective blockade of microRNA processing by Lin28. Science. 2008; 320(5872):97-100. PMC: 3368499. DOI: 10.1126/science.1154040. View

11.

Levy C, Khaled M, Robinson K, Veguilla R, Chen P, Yokoyama S . Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell. 2010; 141(6):994-1005. PMC: 2897150. DOI: 10.1016/j.cell.2010.05.004. View

12.

Palma J, Yaddanapudi S, Pigati L, Havens M, Jeong S, Weiner G . MicroRNAs are exported from malignant cells in customized particles. Nucleic Acids Res. 2012; 40(18):9125-38. PMC: 3467054. DOI: 10.1093/nar/gks656. View

13.

Abdelmohsen K, Srikantan S, Kang M, Gorospe M . Regulation of senescence by microRNA biogenesis factors. Ageing Res Rev. 2012; 11(4):491-500. PMC: 3348995. DOI: 10.1016/j.arr.2012.01.003. View

14.

Matts P, Fink B . Chronic sun damage and the perception of age, health and attractiveness. Photochem Photobiol Sci. 2010; 9(4):421-31. DOI: 10.1039/b9pp00166b. View

15.

Gallo A, Tandon M, Alevizos I, Illei G . The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One. 2012; 7(3):e30679. PMC: 3302865. DOI: 10.1371/journal.pone.0030679. View

16.

Chikh A, Matin R, Senatore V, Hufbauer M, Lavery D, Raimondi C . iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J. 2011; 30(20):4261-73. PMC: 3199390. DOI: 10.1038/emboj.2011.302. View

17.

Tucker P . Bald is beautiful?: the psychosocial impact of alopecia areata. J Health Psychol. 2009; 14(1):142-51. DOI: 10.1177/1359105308097954. View

18.

Teta M, Choi Y, Okegbe T, Wong G, Tam O, Chong M . Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development. 2012; 139(8):1405-16. PMC: 3308177. DOI: 10.1242/dev.070920. View

19.

Andl T . miRNAs: Miracle or Mirage?: The Limes Against the Barbaric Floods of Leaky and Undesired Transcripts. Organogenesis. 2009; 3(1):25-33. PMC: 2649616. DOI: 10.4161/org.3.1.3670. View

20.

Ivanov S, Goparaju C, Lopez P, Zavadil J, Toren-Haritan G, Rosenwald S . Pro-tumorigenic effects of miR-31 loss in mesothelioma. J Biol Chem. 2010; 285(30):22809-17. PMC: 2906272. DOI: 10.1074/jbc.M110.100354. View