The Role of MicroRNAs in the Healing of Diabetic Ulcers

Overview

Journal Int Wound J

Specialties Emergency Medicine
Orthopedics

Date 2019 Mar 2

PMID 30821119

Citations 14

Authors

Golnaz Goodarzi

Mahmood Maniati

Durdi Qujeq

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small protected molecules with a length of 18 to 25 nucleotides. Many studies have recently been conducted on miRNAs, illustrating their role in regulating many biological, physiological, and pathological activities, such as maintaining cellular signalling and regulating cellular pathways. The main role of miRNAs is to regulate the expression of genes after translation, which can lead to the destruction or suppression of translation by binding to mRNAs. As any change in the regulation of miRNAs is associated with several physiological abnormalities, such as type 2 diabetes and its complications, these molecules can be used for therapeutic purposes or as biomarkers for the diagnosis of diseases such as diabetes and its complications. In this review article, we will discuss important findings about the miRNAs and the role of these molecules in different phases of the wound-healing process of chronic wounds, especially diabetic ulcer.

Citing Articles

Negative pressure wound therapy promotes wound healing by down-regulating miR-155 expression in granulation tissue of diabetic foot ulcers.

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Key extracellular proteins and TF-miRNA co-regulatory network in diabetic foot ulcer: Bioinformatics and experimental insights.

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Peptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis.

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Wang C, Huang L, Li J, Liu D, Wu B Biochem Genet. 2023; 62(4):2437-2454.

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Role of Increased miR-222-3p Expression in Peripheral Blood and Wound Marginal Tissues of Type 2 Diabetes Mellitus Patients with Diabetic Foot Ulcer.

Jie R, Qian J, Tang Y, Li Y, Xu M, Zhao X Diabetes Metab Syndr Obes. 2023; 16:2419-2432.

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