Enantioselective Synthesis of Coumarin Derivatives by PYBOX-DIPH-Zn(II) Complex Catalyzed Michael Reaction

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2012 Sep 11

PMID 22957472

Citations 4

Authors

Sumit K Ray

Pradeep K Singh

Nagaraju Molleti

Vinod K Singh

Affiliations

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Abstract

A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)(2) complex. The methodology has successfully been employed in the synthesis of (R)-Warfarin and another related compounds.

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