Effects of Chorioamnionitis on the Fetal Lung

Overview

Journal Clin Perinatol

Date 2012 Sep 8

PMID 22954262

Citations 48

Authors

Alan H Jobe

Affiliations

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Abstract

Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery. The reported effects of these exposures on fetal lungs are inconsistent because exposure to different organisms, durations of exposure, and fetal/maternal responses affect outcomes. In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia.

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