Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Sep 7

PMID 22951821

Citations 19

Authors

Yifang Xuan

Ling Liu

Sheng Shen

Hongyu Deng

Guangxia Gao

Affiliations

Soon will be listed here.

Abstract

Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to specific viral mRNAs and repressing mRNA expression. Here we report that ZAP inhibits expression of murine gammaherpesvirus 68 (MHV-68) M2, which plays important roles in establishment and maintenance of viral latency. Downregulation of endogenous ZAP in cells harboring latent MHV-68 promoted lytic replication of the virus. These results suggest that ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency.

Citing Articles

Dual Roles of Host Zinc Finger Proteins in Viral RNA Regulation: Decay or Stabilization.

Lee H, Park S, Lim J Int J Mol Sci. 2024; 25(20).

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Versatility of the Zinc-Finger Antiviral Protein (ZAP) As a Modulator of Viral Infections.

Shao R, Visser I, Fros J, Yin X Int J Biol Sci. 2024; 20(12):4585-4600.

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Antiviral Activity of Zinc Finger Antiviral Protein (ZAP) in Different Virus Families.

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Does the Zinc Finger Antiviral Protein (ZAP) Shape the Evolution of Herpesvirus Genomes?.

Lin Y, Chau L, Coutts H, Mahmoudi M, Drampa V, Lee C Viruses. 2021; 13(9).

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Xia T, Li X, Wang X, Zhu Y, Zhang H, Cheng W EMBO Rep. 2021; 22(4):e50128.

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