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ZAP-mediated MRNA Degradation

Overview
Journal RNA Biol
Specialty Molecular Biology
Date 2008 Apr 18
PMID 18418085
Citations 47
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Abstract

The zinc-finger antiviral protein (ZAP) is a host factor that inhibits the replication of many viruses by preventing the accumulation of viral mRNAs in the cytoplasm. ZAP specifically binds to the viral mRNA and recruits the cellular RNA degradation machinery to degrade the target RNA. In this article, we will review the work to date in understanding the mechanisms by which ZAP promotes viral mRNA decay and discuss future research directions to further investigate the function and underlying mechanisms of ZAP.

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