A Mouse Model to Identify Cooperating Signaling Pathways in Cancer

Overview

Journal Nat Methods

Specialties Biomedical Engineering
Pathology

Date 2012 Aug 7

PMID 22863881

Citations 5

Authors

Monica Musteanu

Leander Blaas

Rainer Zenz

Jasmin Svinka

Thomas Hoffmann

Beatrice Grabner

Daniel Schramek

Hans-Peter Kantner

Mathias Muller

Thomas Kolbe

Thomas Rulicke

Richard Moriggl

Lukas Kenner

Dagmar Stoiber

Josef Martin Penninger

Helmut Popper

Emilio Casanova

Robert Eferl

Affiliations

Soon will be listed here.

Abstract

We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.

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