RAS Oncogenes: the First 30 Years

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2003 Jun 5

PMID 12778136

Citations 772

Authors

Marcos Malumbres

Mariano Barbacid

Affiliations

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Abstract

From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction - mainly in human cancer - is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.

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